Substance Guides
Each psychedelic substance has a distinct pharmacological profile, phenomenological character, cultural history, and risk profile. Choose a substance to explore.
Psilocybin Mushrooms
The most researched psychedelic. Effects, dosage, evidence, risks.
Ayahuasca
Sacred Amazonian brew. Ceremony, preparation, cultural context, MAOI interactions.
DMT (N,N-DMT)
Endogenous tryptamine. Smoked breakthroughs, entity encounters, and its role in ayahuasca.
5-MeO-DMT
The most potent psychedelic. Total ego dissolution, short duration, toad controversy.
Mescaline
Peyote and San Pedro. Effects, cultural significance, ethical considerations.
LSD
Semi-synthetic serotonergic psychedelic. Long duration, stimulating character, dosage.
Ibogaine
Powerful anti-addiction compound with serious cardiac risks. Bwiti roots, opioid research.
Ketamine
Dissociative anesthetic now used clinically for depression. Distinct profile and risks.
MDMA
Empathogen used in trauma therapy. Neurotoxicity, heart, and dependence considerations.
Cannabis
Endocannabinoid pharmacology, psychedelic potential, combinations, and real risks.
2C-B
Phenethylamine psychedelic. Effects, dose-dependence, preparation.
Salvia Divinorum
Kappa-opioid agonist. Alien, brief, and disorienting. Mazatec ceremonial roots.
How Long Does Each Psychedelic Last?
Total duration of primary effects by route of administration. The time axis is square-root scaled so twenty-minute and two-day journeys stay comparable — each substance page has the full phase-by-phase timeline.
