Substance Guides
Each psychedelic substance has a distinct pharmacological profile, phenomenological character, cultural history, and risk profile. Choose a substance to explore.
Psilocybin Mushrooms
The most researched psychedelic. Effects, dosage, evidence, risks.
Ayahuasca
Sacred Amazonian brew. Ceremony, preparation, cultural context, MAOI interactions.
DMT (N,N-DMT)
Endogenous tryptamine. Smoked breakthroughs, entity encounters, and its role in ayahuasca.
5-MeO-DMT
Among the most potent psychedelics. Total ego dissolution, short duration, toad controversy.
Mescaline
Peyote and San Pedro. Effects, cultural significance, ethical considerations.
LSD
Semi-synthetic serotonergic psychedelic. Long duration, stimulating character, dosage.
Ibogaine
Powerful anti-addiction compound with serious cardiac risks. Bwiti roots, opioid research.
Ketamine
Dissociative anesthetic now used clinically for depression. Distinct profile and risks.
MDMA
Empathogen used in trauma therapy. Neurotoxicity, heart, and dependence considerations.
Cannabis
Endocannabinoid pharmacology, psychedelic potential, combinations, and real risks.
2C-B
Phenethylamine psychedelic. Effects, dose-dependence, preparation.
Salvia Divinorum
Kappa-opioid agonist. Alien, brief, and disorienting. Mazatec ceremonial roots.
How Long Does Each Psychedelic Last?
Total duration of primary effects by route of administration. The time axis is square-root scaled so twenty-minute and two-day journeys stay comparable. Each substance page has the full phase-by-phase timeline.
What Each Guide Covers
Every substance guide answers the same twelve questions, so you can move between them without relearning where things are. Four further sections appear only where the question has a real answer. Ceremony is a live question for ayahuasca and an empty one for 2C-B, so the gaps in this table carry as much information as the marks.
- What it is
- Where it comes from
- History & cultural roots
- How it works
- Effects
- Dosage
- Research
- Risks
- Verifying what you have
- Legal status
- If you are considering this
- FAQ
| Where it also applies | Ceremony | Ethics | Compared to | Access |
|---|---|---|---|---|
| 5-MeO-DMT Natural | Does not apply | Does not apply | ||
| Ayahuasca Natural | Does not apply | Does not apply | ||
| Cannabis Natural | Does not apply | Does not apply | Does not apply | Does not apply |
| DMT Natural | Does not apply | Does not apply | Does not apply | |
| Ibogaine Natural | Does not apply | |||
| Mescaline Natural | Does not apply | Does not apply | ||
| Psilocybin Natural | Does not apply | Does not apply | Does not apply | |
| Salvia divinorum Natural | Does not apply | Does not apply | Does not apply | |
| LSD Semi-synthetic | Does not apply | Does not apply | Does not apply | |
| 2C-B Synthetic | Does not apply | Does not apply | Does not apply | |
| Ketamine Synthetic | Does not apply | Does not apply | ||
| MDMA Synthetic | Does not apply | Does not apply | Does not apply | Does not apply |
Each mark links straight to that section.