Drug Interaction Checker
Pick two substances to see how they interact. Based on TripSit combination data and peer-reviewed pharmacological literature.
Check a combination
Pick two to see how they interact, or one to see everything it interacts with.
Pick a substance to begin.
Full Interaction Chart
Hover a cell, or tab to the chart and use the arrow keys, for the note. Click a cell or press Enter to open that pair above.
Understanding Risk Categories
These substances tend to enhance each other’s effects in generally predictable ways. Standard harm reduction practices apply, but the combination does not introduce novel dangers beyond those of each substance alone.
No significant interaction expected at typical doses. The combination is not known to produce dangerous effects, though individual variation always applies.
One substance reduces or blocks the effects of the other. Not typically dangerous, but may result in a diminished or unpredictable experience.
The combination carries moderate risk or produces unpredictable interactions. Additional research, dose reduction, and careful monitoring are advisable.
The combination carries significant risk. Serious adverse effects (cardiovascular strain, extreme psychological distress, serotonin toxicity, or respiratory depression) are possible.
The combination carries life-threatening risk. Serotonin syndrome, seizures, cardiac events, or respiratory failure are documented possibilities. Do not combine.